摘要
本文分析了300例氟中毒病人SLDH(血清乳酸脱氢酶)同工酶谱,在同一标本上可同时观察到各种LDH同工酶活性绝对值,借以推测有关组织受危害状态,及其危害的主要靶器官。对氟中毒病人检查是一项很有价值舶容观指标。氟中毒病人的同工酶谱的主要特点是:(1)SLDH同工酶总活性呈中等度以上增加;(2)LDH_1～LDH_5活性都有不同程度增加;(3)LDH_5的活性增加程度最为突出;(4)LDH_1/LDH_2活性的增加也高于健康组。这些特点反映了氟中毒是全身性受损害的疾病,受损害的主导器官是骨骼肌,此外心肌、肺脏,也受到一定度度损害。
The zymograms of isoenzymes of SLDH from 300 patients with endemic fluo-rosis were analysed and the absolute active values of aJJ the isoenyzes of LDH were obrained simultaneously, thereby, the functional conditions of the associa- ted tissues could be estimated, which was of great value in the diagnosis of fiuorosis. The main characteristics of the zymograms were as followings:
l.The total activity of the isoenzymes increased moderately or highly.
2.The activity of all the isoenzymes from LDH1 to LDH5 increased in various degrees.
3.The activity of LDH5 increased most obviously.
4.The value of LDH1/LDH2 was greater than that of the control group.
It was indicated in this study that fluorosis was systemic toxicosis, lesions were chiefly detected in skeletal muscles and next in cardiac muscle and the lungs.
出处
《地方病通报》
1989年第1期70-73,共4页
Endemic Diseases Bulletin
