摘要
通过建立５／６肾切除（５／６Ｎｘ）大鼠慢性肾衰动物模型，测定残余肾小球抗氧化酶－超氧歧化酶（ＳＯＤ）及胱氮酸过氧化物酶（ＧＳＨ－Ｐｘ）活性和脂质过氧化物酶（ＭＤＡ）。结果示５／６Ｎｘ术后８周及１２周，大鼠血清肌酐上升，肌酐清除率下降，病理上出现明显肾小球硬化的同时，残余肾小球ＳＯＤ及ＧＳＨ－Ｐｘ活性均明显低于正常对照织（Ｐ＜０．０５），而ＭＤＡ量却显著增加（Ｐ＜０．０５）。提示慢性肾衰大鼠残余肾组织抗氧化功能不全，氧自由基的产生及清除失平衡可能参与了慢性肾功能不全的发生和发展。
norder tu investigate the role uf
antioxidase in the model of rat’chronic renal failure by 5/ 6 nephroectomy,the
antioxidase-superoxide dismutase (SOD),the activity of glutathione-peroxidase(GSH-Px )and
lipo-peroxidase(MDA )were measured, The results showed that in the 8th and 12th week after
5/ 6 nephroectomy with the serum creatinine inereased,Cer decreased,and glomerular
sclerosis happened,the activity of SOD and GSH-Px uf remnant glomeruli was much luwer than
the normal control group(P<0. 05),but the MDA significantly increased (P<0.05).It suggested
that the disfunction of antioxydization of the rat’remnant kidney tissue of chronic renal failure
existed,and the creation of oxygen radicals and isbalance of clearence may take part in the
occurence and development of chronic renal failure.
出处
《肾脏病与透析肾移植杂志》
CAS
CSCD
1994年第3期165-168,共4页
Chinese Journal of Nephrology,Dialysis & Transplantation
