摘要
作者对３４例系统性红斑狼疮（ＳＬＥ）孕妇及２３例正常孕妇进行胎盘病理学检查和胎儿脐动脉、子宫动脉血流量测定，结果：ＳＬＥ孕妇胎盘重量明显低于正常孕妇组（Ｐ＜０．００１）。胎盘绒毛面积之比小于正常孕妇组（Ｐ＜０．０１）；扫描电镜观察见：绒毛外观纤细、分枝较少，末梢绒毛豆芽状，绒毛表面有多个针尖样小孔，还可见到崩裂团块；免疫组化提示在蜕膜、绒毛上可见到ＩｇＧ、ＩｇＡ、ＩｇＭ、Ｃ３沉积，提示ＳＬＥ孕妇胎盘受到免疫攻击；ＳＬＥ孕妇胎儿脐动脉血流Ｓ／Ｄ、ＲＩ、ＰＩ均大于正常孕妇组（Ｐ＜０．０５），而ＳＶ、ＶＦ、ＰＭ均小于正常对照组（Ｐ＜００１）：病例组左侧子宫动脉血流Ｓ／Ｄ、ＲＩ、ＰＩ明显高于正常对照组（Ｐ＜０．０５），ＳＶ、ＶＦ、ＰＭ小于正常对照组但无显著性差异。
Pathological examination of placenta and blood flow volume assay in umbilical and uterine arteries were carried out in 34 cases of pregnancy complicated with systemic lupus erythematosus(ELE)using 23 cases of normal pregnancy as control.Results Showed that the volume and weight of placenta in the diseased group were significantly lower than those in the control(P<0.05).The terminal portion of villi under scanning electron microscope was bean sprout shaped with multiple pin-point holes on the surface,in addition to the disrupted masses.Immuno-histochemical study demonstrated that there existed a deposition of IgG、IgA、IgM、C3on the surface of uterine decidua and villi. Thase suggested that the placenta might have been injured by disease.The blood flow-volum of umbilical artery expressed as the ratio of systolic and diastolic peak values(S/D),resistance index(RI),Pulsatile index(PI)in pregnant women with SLE were all higher than those in the control(P<0.05)and the stroke volume(SV),volume flow per minute (VFPM)in the diseased group were lower than those in the control(P<0.005) while S/D、 RI、 PI of the left uterine artery were higher.
出处
《上海第二医科大学学报》
CSCD
1994年第4期285-290,共6页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
红斑狼疮
妊娠
胎盘病理
脐动脉血流
systemic lupus erythematosus
pregnancy
blood flow-velocity
umbilical artery uterine artery
placenta
