摘要
从糙皮侧耳真菌中提取出糖肽（Ｐ．ＯｓｔｒｅａｔｕｓＧｌｙｃｏｐｅｐｔｉｄｅｓ，ＰＯＧＰ），进一步分离成为高、低分子量组分。实验表明，ＰＯＧＰ有促进ＬＡＫ细胞和ＮＫ细胞杀伤肿瘤细胞的作用；药理试验显示有抑制小鼠Ｓ１８０瘤细胞增殖和向周围组织侵袭的作用；病理检测见ＰＯＧＰ可致瘤组织坏死，淋巴细胞浸润，并形成较厚的纤维包膜。提示ＰＯＧＰ具有使肿瘤组织纤维化的作用。此外，低分子组分较高分子组分有更好的口服吸收性。
One of glycopeptides, named POGP, was extracted from P. Ostreatus fungi, advance fractionated by superfilter to high and low molecular weight components (POGP-H, POGP-L). The antitumor activity afteroral administration on POGP-L group was higher than in POGP-H group.In vitro,POGP could enhance the activity of LAK cellsand NK cells to tumor cells.In vivo, it could inhibit the infiltration of tumor cells into surrounding normal tissues, as well as the proliferation of S180 cells. In pathological study, POGP could lead to death of tumor tissue, infiltration by lymph cells and formation of fibrointegument with certain thickness. The results suggested that POGP may be used to stimulate the increase of fiber in tumor tissue.
出处
《山东医科大学学报》
1994年第4期343-346,共4页
Acta Academiae Medicinae Shandong
关键词
糙皮侧耳
糖肽类
自然杀伤细胞
免疫活性
Pleurotus Ostreatus
Glycopeptides
LAK cell
Killercells.natural
Immunocompetence
Antitumor action
