摘要
向大鼠杏仁基底内侧核（ＢＭＡ）内微量注射八肽胆囊收缩素（ＣＣＫ－８）、ＣＣＫ受体阻断剂（Ａ型或Ｂ型），进行胃内压和胃运动的记录和分析。结果如下：ＣＣＫ－８（５０ｎｇ／１μｌ）注射后胃内压（ＩＧＰ）和胃蠕动频率（ＧＭＦ）显著下降（Ｐ＜０．０１）；单独微量注射ＣＣＫ－Ａ受体阻断剂Ｌ３６４７１８（１００ｎｇ／１μｌ）或ＣＣＫ－Ｂ受体阻断剂Ｌ３６５２６０（１００ｎｇ／１μｌ），对胃内压和胃运动无明显影响；先给Ｌ３６４７１８（１００ｎｇ／１μｌ）再给予ＣＣＫ－８，则ＩＧＰ，ＧＭＦ的抑制不再出现；先给Ｌ３６５２６０则ＣＣＫ－８对ＩＧＰ和ＧＭＦ的抑制仍出现；在ＢＭＡ附近，如终纹连合部（ＢＳＴＩＡ）和杏仁皮质核（ＰＬＣｏ）内注射ＣＣＫ－８均不出现胃内压、胃运动的抑制作用。提示，ＢＭＡ内ＣＣＫ－８对胃运动、胃内压有抑制作用，这种抑制作用与ＢＭＡ内的ＣＣＫ－Ａ受体有关，而ＣＣＫ－Ｂ受体可能不参加此抑制作用。
Esperiments were carried out on 40 rats to study the effects of microinjections of cholecystokinin-8(CCK-8), L364718 and L365260 into the bilateral basomedial amygdaloid neucleus(BMA) on thd gastric motility and intragastric pressure. The results were as follows :(1)microinjections of CCK-8(50 ng/1μl)resulted in significant decreases of the intragastric pressure(IGP) and gastric motility frequency(GMF)(P<0. 01).(2)Neither the CCK-A receptor antagonist L364718 nor the CCK-B receptor antagonist L365260 induced any effects on the IGP or GMF when given alone.(3) If the bilateral BMA were pretreated with L364718 CCK-8 could not induce any inhibitive effects,which, however,appeared when L365260 was given first.(4)The inhibitive effects were not found in other nuclei in the amygdaloid body, such as BSTIA and PLCo. The above findings suggest that CCK in BMA are involved in the inhibition of gastric motility and intragastric pressure and that the activation of the CCK-A receptor, not that of the CCK-8 receptor, may be the mechanism.
出处
《青岛医学院学报》
1994年第3期176-179,共4页
Acta Academiae Medicinae Qingdao Universitatis
关键词
八肽胆囊收缩素
胃内压
胃运动
杏仁核
cholecystokinin-8
intragastric pressure
gastric motility
basomedial amygdaloid
rats
