摘要
采用单克隆抗体间接免疫荧光法,检测胃癌患者手术前后外周血淋巴细胞和体外培养的激活 T 细胞 DR 抗原表达,同时对 DR 抗原与 T 细胞亚群的相关性进行分析。结果表明,胃癌患者手术前后 DR 抗原表达明显降低,其下降与 CD_4^+细胞和 CD_4^+/CD_8^+值呈正相关。西米替丁在体内、外可增强 DR 抗原表达。
The expression of HLA-DR antigen on the peripheral blood lymphocyte and activated T cells and correlation of the expression of HLA-DR antigen with T lymphocyte subsets were investigated in patients with gastric cancer pre-and post-operation,by monoclonal antibodies and indirect immunoflurescence technique. The results showed that the ability of peripheral blood T lymphocyte to express HLA-DR antigen was significantly decresaed before and after operation. There was significant correlation of expression of HLA-DR antigen with CD_4 posi- tive cells and CD_4:CD_8 ratio. Cimetidine could enhance the expression of HLA-DR antigen in patients with gastric cancer in vivo and vitro.
出处
《湖南医科大学学报》
CSCD
1994年第3期235-238,共4页
Bulletin of Hunan Medical University
关键词
胃肿瘤
癌
人白细胞抗原
淋巴细胞
西米替丁
stomach neoplasms
cancer
HLA-DR antigens
T lymphocyte subsets
cimetidine
