摘要
以硫氢化钠作巯基化剂，取代氯乙酸中的氯来合成巯基乙酸。实验确定ＮａＨＳ溶液浓度为１５％左右，加完氯乙酸后反应时间控制在２．５ｈ以内；加料完毕，应向反应液中鼓人Ｈ＿２Ｓ气体。产品含量高于９６％，反应产率约为９２％。该方法工艺简单、成本低、原料易得。建议国内开发该工艺路线。
Mercaptoacetic acid is synthesized, using sodium sulfhydrate as sulfhydryl agent which is substituted for chlorine in chloroacetic acid.It is determined experimentally that concentration of NaHS is about 15%,reaction time is controlled within 2.5 h after chloroacetic acid had been added;after the enrich ended, H_2S gas is blasted into reaction liquid.Content of the product is above 96%,reaction yield is about 92%, The process is very simple,of low cost and its raw materials are given easily,It is suggested that the process be developed at home.
出处
《河北化工》
1994年第2期13-15,共3页
Hebei Chemical Industry
关键词
巯基乙酸
硫氢化钠
氯乙酸
硫酸
mercaptoacetic acid, sodium sulfhydrate,chloroacetic acid, sulfuric acid, hydrochloric acid, ethyl acetate
