摘要
在浓硫酸作用下，由５－（５－苯基－２Ｈ四唑－２－乙酰基）－４－芳酰氨基硫脲１ａ～ｎ制得了一系列新的２－芳酰氨基－５－（５－苯基－２Ｈ－四唑－２－甲基）－１，３，４－噻二唑化合物（２ａ～ｎ）。所有化合物的结构均经元素分析、ＭＳ分析，部分代表化合物经ＩＲ、￣ＨＮＭＲ分析确证；初步观察了２ａ～ｎ在１％浓度下对大肠杆菌（Ｇ￣－）的抑制作用，发现２ｄ，２ｅ，２ｆ，２ｎ显示出较强的活性。
Fourteen new 2-aroylamino-5-(5-phenyl-2H-tetrazol-2-ylmethyl)-1,3,4-thiadia-zoles 2a～n were synthesized by cyclization of 1-(5-phenyl-2H-tetrazol-2-acetyl)-4-aroylth-iasemicarbazides la～n in conc. H_2SO_4 at 0℃. The structure of compounds 2a～n were confirmed by elementary analysis,IR,￣1HNMR and MS.Compounds 2a～n were screened for their antifungal activity against E. Coli(G￣-)at 1%. The results show that 2d,2e,2f and 2n have stronger inhibiting effects.
出处
《合成化学》
CAS
CSCD
1994年第4期330-333,共4页
Chinese Journal of Synthetic Chemistry
关键词
芳酰氨基硫脲
噻二唑
衍生物
合成
抗菌活性
Thiosemicarbazides,1,3 ,4-Thiadiazoles,Synthesis ,Antifungal activity.
