摘要
疼痛是癌症病人尤其是晚期癌症患者常见的症状。据世界卫生组织(WHO)统计,全世界每年有600万新发生的癌症病人,其中半数发生于发展中国家,在诊断时常常已处于晚期。每年全世界有4300万人死于癌症;其中有3500万有不同程度的疼痛。但有相当多的人得不到合适的处理。因之,WHO将癌症疼痛的治疗列为重点研究课题之一,并组织有国际性协作组,编辑专著和小册子。近年来提出一个口号“到2000年让癌症病人不痛”。 WHO认为疼痛被忽视的原因有:(1)
The results of Aminophenedeine (each tablet containing Acetaminophen 500 mg and Codeine phosphate 8.4 mg) in cancer pain relief of 93 cases in a prospective collaborative study are pre- sented. Patients with various cancer suffering from different degree of pain were first treated with Qutongpian (a non-morphine pain killer, each tablet containing Acetaminophen 100 mg, Aminopyrin 150 mg, Caffeine 50 mg and Phenobarbital 15 mg) for 3 days, and then changed to Aminophenedeine for 7 consecutive days. Dosage for adults was 1～2 tablets orally 2～3 times every day. Complete relief of pain was observed in 20 cases (21.5%), marked relief in 21 cases (22.6%), mild relief in 7 cases (7.5%) and no effect in 14 cases (15.1%) after treatment of Am- inophenedeine; there were 3.4%, 10.1%, 23.6%, 11.2% and 51.7% respectively in the same group of patients after receiving Qutongpian. Analysis of the factors such as the age of patient, degree and site of pain, and the previous treatment in correlation with pain relief efficacy revealed that the degree of pain and the drugs used before treatment were the most important factors influencing the results of Aminophenedeine. This drug is indicate in patients with mild or intermediate degree of cancer pain; while drugs belonging to strong morphones should be given in the patients with severe cancer pain. Side effects of Aminophenedeine were mild. There were only a few patients with nausea,dizziness,drowsiness which did not limit the continuation of drug administration. Mild skin rash was observed in one patient.
出处
《实用肿瘤杂志》
CAS
北大核心
1989年第1期12-15,共4页
Journal of Practical Oncology
