摘要
本实验测定锌缺乏时小鼠周围血淋巴细胞（ＰＢＬ）对有丝分裂ＣｏｎＡ刺激反应的改变。当用不同锌含量的合成饲料饲养Ａ／Ｊ小鼠２８天后，缺锌组小鼠体重和总食物消耗明显减少，体重仅为对照组的６８％。当用５μｇＣｏｎＡ／ｍｌ刺激ＰＢＬ时，中度和重度缺锌组细胞３￣Ｈ－ＴｄＲ掺入显著减少，分别为对照组的５２％和３１％，而限制组与对照组相比无明显改变。结果说明：缺锌时周围血淋巴细胞免疫功能受到严重损害，而不是由于食物摄入不足所致。
The response of peripheral blood lymphoctes (PBL) from zInc deficient mice to Con Awere measured. During a 28 days feeding period with synthetic diet containing different levels ofzinc, the body weight of zinc deficient mice were gradually lost and only 68%in comparison withthe control group. The incorporation of 3￣H-TdR in moderate and severe zinc deficient groups,when PBL were stimulated by Con A, were reduced and only 52%and 31% in comparison withthe contral respectively, but no alteration was observed in restricted group. The data suggestthat the immunological function of PBL are impaired that is not a result of reduced food intakewhen zinc is depleted from body.
出处
《海南大学学报（自然科学版）》
CAS
1994年第1期36-38,共3页
Natural Science Journal of Hainan University
关键词
锌缺乏
鼠科
淋巴细胞
增殖
抑制
zinc deficiency, immune system, peripheral blood, lymphocyte, mitogen
