摘要
用食饵性高血脂及食饵性高血脂加免疫性动脉内皮损伤的方法建立兔动脉粥样硬化模型,观察到随着动脉粥样硬化形成,红细胞变形性降低,红细胞膜胆固醇及磷脂含量增高,红细胞膜及血清脂质过氧化物含量增高,而红细胞超氧化物歧化酶活力降低.这些损害与动脉粥样硬化病变的发生和发展有着密切的关系.
We established the model of experimental atherosclerosis in rabbits produced by dietary hyperlipidemia,and dietary hyperlipidemia combined with the immunopathologic endothelial injuries. We observed that when atherosclerosis occured, the deformity of the red cells decreased, thecontents of cholesterol and phospholipid of red cell membrane increased, the contents of lipoid peroxidates of the red cell membrane and serum increased too ,but superoxide dismutase activity of the redcells decreased. These changes were closely related with the occtirence and progression of atherosclerosis.
关键词
动脉粥样硬化
红细胞
脂质过氧化物
膜脂质
<Keyword>Rabbits
Atherosclerosis
Red cell
Lipoid Peroxidation
Superoxide dismutase
