摘要
用不同来源的４株马尔尼菲青霉菌株，以及同种来源但传代次数不同的菌株分别感染小鼠，以观察马尔尼菲青霉对组织的侵袭力，致病性以及小鼠的抗体产生率。结果发现：①不同来源的菌株其免疫原住有差异；②同一来源但经反复传代培养后的菌株其免疫原性显著下降，但不伴有组织侵袭力及致病能力的改变；③各种菌株均对小鼠富含巨噬细胞的组织具有很强的亲和力，均能引起以化脓性炎为特点的病变，且病变的形态及轻重程度均较稳定。对马尔尼菲青霉菌的致病机制，血清学检查特异性抗体出现假阴性的原因进行探讨，并筛选出免疫原性较强的菌株以便进行抗体生产。
he invasiveness and pathogenicity of different strains of Penicillum marneffei werestudied. The rate of antibodies appearence in the mice after inoculated with P. maneffei was also observed.We found that :1)Different strains possess different immunogenicity. 2)After repeated genetic transmission,the strength of the immunogenicity of the strain diminished,but without any changein its invasiveness and pathogenicity,3)All strains of P. marneffei were easily found in the tissueswhich were rich in macrophages. All of them could cause characteristic suppurative reactions.The purpose of this research was to find out the pathogenesis of P. marneffei,the reasons for false-negative reaction in serological test,and to isolate a strain possessing the strongest immunogenicity for antibodyproduction.
出处
《广西医科大学学报》
CAS
1994年第2期128-132,共5页
Journal of Guangxi Medical University
关键词
马尔尼菲
青霉菌
免疫原性
致病力
Penicillium marneffei
Immunogenicity
Pathogenicity
