摘要
大鼠蛛网膜下腔注射强啡肽Ａ１－１３后产生剂量相关、部分可逆性后肢瘫痪，而蛛网膜下腔注射μ受体激动剂ＤＡＧＯ、δ受体激动剂ＤＡＤＬ不产生后肢功能障碍。结果提示：强啡肽Ａ在脊髓继发性损伤中起了较为重要的作用，其致瘫作用可能系强啡肽Ａ与ｋ受体相互作用的结果。
We reported that dynorphin A(1-13)administered intrathecally caused dose-related and partially reversible hindlimb paraplysis in the unanesthetized rat.While other opioids, including μ-selective and δ-selective synthetic enkephalins,failed to induce motor dysfunction.These findings suggest that dynorphin or dynorphin-related peptides may play a role in spinal cord injury.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1994年第4期306-309,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金
关键词
强啡呔
阿片
受体
脊髓损伤
瘫痪
dynorphin
opiate receptor
spinal injury
rats
