摘要
利用免疫组织化学方法,对39例子宫颈癌(5例原位癌。3例早期浸润癌,31例浸润癌)组织石腊包理标本进行了P53表达的检测,结果发现39例子宫颈癌标本中.19例有P53的高表达(48.7%)(2例原位癌、且例早期浸润癌、16例浸润癌)。还发现P53高表达阳性率在分化较好的浸润癌相对较低(42.9%),在分化较差的浸润癌相对较高(75%)。这些结果表明P53的高表达在子宫颈癌的发生中是一个比较常见的基因改变,P53高表达的阳性率与子宫颈癌的分化程度有关。
In normal cells,p53 protein is virtually undetectable by immunohistochemical methods. Mutation of p53 gene results in overexpression of the protein and thus levels of p53 detectable by immunohistochemical methods. We studied the expression of p53 protein in human cervical carcinoma (39 cases)paraffin embedded tissue sections by immunohistochemical methods.Of these cervical carcinoma specimens overexpression of P53 protein was showed in 19 cases (48.7%) and was a higher percentage in low differentiation rodent cancer (75%) than in high differentiation rodent cancer(42.9%). These results suggested that overexpression of p53 often occurred in cervical carcinoma and that the percentage of overexpression of p53 Was tight relative to the differentiation degree of human cervical carcinoma.
出处
《长治医学院学报》
1994年第4期286-288,共3页
Journal of Changzhi Medical College
