摘要
用电子自旋标记研究铅对人红细胞膜脂质及膜蛋白的作用，并观察了尼克酰胺的保护作用，结果表明，在一定量的铅作用下，膜脂质表层及深层均无明显变化，膜蛋白则变化较明显，尼克酰胺具有膜保护作用，可拮抗铅对膜蛋白的影响。说明铅主要作用于红细胞的膜蛋白，而不是膜脂质，铅对红细胞膜的损伤主要与膜蛋白构象改变有关。
The
effects of lead on lipid and protein of human erythroeyte membrane
membrane and protective effect of nicotinamide were investigated
using the electron spin labeling method .The results showed that no
change was seemn in fiuldity of membrane lipids while singmificant
change appeared in membrane protein treated with lead .Nicotinamide
has protective effect on the protein of membrane treated with lead.
The results indicate that lead acts more pronouncedly on membrane
protein than on the lipid bilayer.
出处
《北京医科大学学报》
CSCD
1994年第3期186-187,204,共3页
Journal of Peking University(Health Sciences)
关键词
铅
红细胞膜
电子自旋标记
Lead Eryhrocyte membrane,
Spin Label
Nicotinamide
