摘要
本文采用逆相蒸发法制备了Ｉｒｎａ大单层脂质体，包封率为３２．５～３８．２％。通过１２５Ⅰ标记的Ｉｒｎａ，观察１２５Ｉ－Ｉｒｎａ脂质体及游离的１２５Ｉ－Ｉｒｎａ在静脉给药后主要脏器药物的分布，表明脾脏和肝组织对Ｉｒｎａ脂质体有较高的摄取，Ｉｒｎａ脂质体能够延长Ｉｒｎａ在体内的作用时间。
The liposome containing125I-irna of
large unilamellar vesicles were preparedby the reverse phase evaporation method, with
theencapsulation cfficiency rangingfrom 32.5%to 38.2%. Through observation of125Ilbelledirna
after i.v. injection· the comparative dis-tribution of i-RNA in some of the chief organs in mice,
including125I-iRNAentrapped in lipo-some or free125I-iRNA was determined. the results showed
that thespieenand the liver hadhighliposome uptake. The interaction timee of iRNA in mice was
increased with liposome con-taining125I-IiRNA.
出处
《白求恩医科大学学报》
CSCD
1994年第3期235-236,共2页
Journal of Norman Bethune University of Medical Science
关键词
IRNA
脂质体
肿瘤
RNA/IM
liposomes
spleen/AN
liver/AN
