摘要
作者观察了重组人粒系集落刺激因子（ｒｈＧ－ＣＳＦ）对ＨＬ一６Ｏ细胞和原代培养的急性髓系白血病（ＡＭＬ）细胞的作用，结果显示，ｒｈＧ一ＣＳＦ可刺激白血病细胞生长，并诱导部分ＡＭＬ细胞向粒系分化。提示ｒｈＧ一ＣＳＦ对白血病细胞存在着增殖与分化的双重作用，这种作用对改进白血病治疗可能产生重要影响。
The effects of recombinant human G-CSF(rhG-CSF)on proliferation anddifferentiation of HL-60 cells and primacy cultured hunian acute myeloblastic leukemia(AML)cells in vitro were investigated,Our data showed that rhG-CSF stimulated the growth of leu-kemic cells and induced granulocytic differentiation of AML cell in 6/ll cases after 6-dayculture.This differentiation was accompanied by morphological, nitroblue tetrazolium(NBT)reduction activity and cy tochemical evluence.The results obtained in this sludy indicate thatrhG-CSF may have the dual action of proliferation and differenti ation on leukemic cells whichwould produce important influence to improve the tleatment of leukemia
出处
《癌症》
SCIE
CAS
CSCD
北大核心
1994年第1期29-31,34,共4页
Chinese Journal of Cancer
关键词
粒系
集落刺激因子
白血病
细胞
Granulocyte colony-stimulating factor Leukemic cell Proliferation and differentiation
