摘要
用多种抗人B细胞抗体和免疫组织化学技术,研究了15例胎儿和儿童胸腺内星状细胞抗原的表达。结果证实,胸腺髓质除一般B细胞外,还有一种特别大并有少数突起的细胞。该细胞除不与OKB-2抗体反应外,均能与抗人IggM、IgD、IgA、Leu14,BA-1、HLA-DR抗体以及抗人K轻链抗体起反应,但不与抗T细胞或抗滤泡树突状细胞的抗体反应,同时也缺乏ANAE的活性。该细胞在胎儿胸腺常位于皮、髓质交界处,而在儿童的胸腺内,则分布于髓质或胸腺小体周围。其功能尚不清楚,可能与T细胞分化成熟有关。由于星状细胞在形态上与滤泡树突状细胞、交错突细胞相似,故对其间关系进行了讨论。
9 fetal and 7 juvenile thymuses were used to identify the asteroid cells on the frozen sections by immunohistochemical method. The results indicated that the thymic medulla, except B cells, contains a type of larger cells with small cytoplasmic processes, which has in common with B cell antigens, such as 1gM, 1gA, Leu14, BA-1, HLA-DR and light chain-Kappa, but they do not express OKB-2. Moreover, the asteroid cells do not reactive with T cell antibody and follicular dendritic cell antibody, and lack of ANAE activity. The asteroid cells in the fetal thymus are constantly located in the corticomedullary region, while, in the juveniles, the asteroid cells are mainly distributed within medulla or in the vicinity of Hassall's corpuscles. As regards the function of asteroid cells is not clear. Based on their distribution, it is probably associated with T cell maturation. On the morphologic ground, the asteroid cells are similar to interdigitating cells in thymus, the relationship between them has been discussed.
出处
《解剖学报》
CAS
CSCD
北大核心
1993年第1期79-83,T009,12,共7页
Acta Anatomica Sinica
关键词
B细胞
胸腺
免疫组织化学
B cell
Asteroid cell
Thymus
Immunohistochemistry
Human
