摘要
通过对10例空间隔缺损(VSD)并中、重度肺动脉高压(PH)患者右心房肌超微结构的观察,发现心肌微丝不同程度溶解消失,且在溶消区内可见粗面内质网池扩张,脂褐素增多及脂质小滴的出现;线粒体增生,其大小不等,分布不均,部分线粒体嵴消失,发生退行性变及基质电子密度降低;部分闰盘双膜间隙扩张,心肌纤维结缔组织增生。这些改变,可能与心肌慢性缺血缺氧有关。
The electromicroscopic observation of atrialbiopsy was carried out in 10 patients with ventric-ular septal defect (VSD) and middle, severe pul-monary hypertension (PH). The observation sug-gests that there are myofibrillar lysis to disappearwith various degrees, dilated rough endoplasmreticulum and the increase in lipofuscin granulesand lipid droplets; mitochondral hyperplasia, theirsize and shape being different, disorganizing of mi-tochondria, disintegration of cristae, mitochondralretrograde degenration and decreased matrix elec-tron density. The dilated intercalated discs and in-crease in myocardial fibrous tissue were found inpart of patients. These structural changes areprobably due to chronic myocardial ischemia.
出处
《西安医科大学学报》
CSCD
1993年第3期195-197,T001,共4页
Journal of Xi'an Medical University(Chinese)
关键词
室间隔缺损
肺动脉高压
心肌活检
ventricular septal defect(VSD)
pulmonary hypertension (PH)
atrial myocardium biopsy
ultrastructure
