摘要
测定肾上腺素(Adr)诱发家兔心律失常后血浆及组织匀浆中脂质过氧化物代谢产物丙二醛的含量变化。发现血浆及组织匀浆中MDA含量明显增加,奎尼丁(Qui)6 mg·kg^(-1),iv,西米替丁(Cim)37.5mg·kg^(-1),iv,及两药剂量减半后合用均能有效地防上Adr诱发的定性心律失常,并能显著抑制MDA的生成,但以合用组效果更显著。
The content of malondialdehyde (MDA) , a metabolite of lipid peroxide (LPO) , in plasma and tissue homongenate from rabbits with arrhythmias induced by adrenaline (Adr) was determined. The results showed that the MDA level was increased in plasma and tissue homogenate. Quinidine (Qui) 6 mg · kg-1, Cimetidine (Cim) 37. 5 mg·kg-1, and 1/2 dose of both drugs administered intravenously could
significantly prevent ventricular arrhythmias induced by Adr and inhibit the production of MDA. The findings suggest that the effect of Qui and Cim on arrhythmias induced by Adr may associate with its inhibition on lipid peroxi-dation.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1993年第5期362-364,共3页
Chinese Pharmacological Bulletin
关键词
奎尼丁
西米替丁
抗心律失常药
Quinidine
Cimetidine
adrenaline
arrhythmia
lipid peroxidation
