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中小学生HBV感染状况调查及痘苗重组DNA乙肝疫苗免疫效果初步观察

Studies on HBV Infection end Effect of Hepatitis B Vaccination with Recombinant Vaccinia Virus among Middle School Students and Pupils
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摘要 1991年6月对808名中小学生进行HBV标志血清学检查,HBsAg阳性率4.33%;抗-HBs阳性率25.37%;抗-HBc阳性率33.91%;HBV感染率40.84%。HBV感染者中抗-HBc阳性比例最高(83.94%),其次抗-HBs,单测HBsAg仅能发现10.61%的HBV感染者。HBV感染者中单项抗-HBs阳性占15%,其中59.18%达到保护水平。对223名乙肝易感者接种痘苗重组DNA乙肝疫苗,首针免疫后一个月抗-HBs阳转率达到46.64%;首针免疫后三个月抗-HBs阳转率达到98.65%。 Blood specimens from 808 middle school students and pupils were detected for HBV-M in June, 1991. The infection rate was 40. 84%. The positivity rates of HBsAg,anti-HBs and anti-HBc were 4.33% ,25.37% and 33.94% ,respectively. Of 330 HBV infected subjects,83.94% were anti-HBc positive,while 10.61% HBsAg positive, when anti-HBc and anti-HBs were detected in combination, 99.39% of HBV infected subjects were found. Among 49 anti-HBs positive subjects, 59.18% effected autoimmune protection. Recombinant vaccinia virus prepared in Beijing was applied to immunize 223 HBV-M negative subjects. Seroconvertion rates of anti-HBs in vaccinated subjects were 46.64% and 98.65% for one and three months after the initial vaccination.
出处 《中国学校卫生》 CAS 北大核心 1993年第3期157-158,共2页 Chinese Journal of School Health
关键词 感染率 DNA 乙型肝炎 疫苗 阳转率 HBV infection recombinant vaccinia virus seroconvertion rate of anti-HBs
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