摘要
493名健康献血员和192例HBV感染者,用ELISA法检测抗—HAV—IgM和抗—HCV,发现献血员之HCV感染率为1.62％。HBV感染者的HAV、HBV二重感染率为16.7％,HBV、HCV二重感染率为3.13％,HAV、HBV、HCV三重感染率为0.52％。重叠感染者,32例HAV和HBV二重感染者,HBeAg 28例转阴,与153例单纯HBV感染者57例转阴比较,有显著性差异(p<0.05)。32例甲、乙肝二重感染者,肝功复常天数(30.3±12.1)与230例单纯甲肝复常天数(25.5±13.5)比较,也有显著性差异。HBV和HCV二重感染以及HAV、HBV、HCV三重感染者,也使HBeAg转阴,病情重、病程长。这些结果提示,甲、乙、丙型肝炎重叠感染比单一感染者的预后差,不少甲型肝炎慢性化可能是重叠感染乙肝或/及丙肝的缘故。
Using ELISA method ,anti-HAV-IgM and anti-HCV were determined between 493 blood donors in good health and 192 patiants with HBV infection. The positive rate of anti-HCV in blood donors was 1.62%. The superinfection rates of HBV and HAV , HBV and HCV,HBV,HAV and HCV in patients with HBV infection were 16. 7% 3. 13% and 0. 52% respectively. The incidence of Hepatitis B viral replication marker was found lower in patients with superinfection of type A and B and/or C hapatitis than those with HBV infection alone. The prolonged course was found longer and the disease degree was severer in patients with superinfection of type A and B and/or C hapatitis than those HAV or HBV or HCV infection alone. The results suggest that in those patients with superinfection of type A and B and/ or C hepatitis poor prognosis and long prolonged course show, while many patients with chronic type A hepatitis result from super inf action HBV and/or HCV.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1993年第5期8-10,共3页
Chinese Journal of Zoonoses
关键词
病毒性肝炎
重叠感染
Type A. B. C hepatitis, Superinfection.
