摘要
本实验结果显示300—500μW·min/cm^2剂量的紫外线照射减毒日本血吸虫尾蚴免疫小鼠可使之产生抗血吸虫感染的能力,所得减虫率分别为48.70％、68.97％、60.00％。100和700μW·min/cm^2的照射剂量所获减虫率明显低于上述水平,分别为10.62％和20.17％。免疫次数与免疫力之间并不相关,免疫一次、两次和三次所得的减虫率分别为68.97％、69.46％和71.16％,无显著性差异。免疫有效期研究表明,小鼠所获的抵抗力至少可达5个月。一个月、三个月和五个月所获减虫率分别为71.28％,69.63％和60.26％,七个月所获减虫率为46.25％,虽与它们有显著性差异,但仍有明显的保护效果。
Effective resistance against S.japonicum was induced by prior exposure to ultraviolet-attenuated cercariae of S. japonicvm with 300, 400 and 500μW·min/cm2 in mice, with reduction percentage of worm burden (RPWB) of 48. 70%, 68. 97% and 60. 00% respectively. The RPWB immunized with l00and 700μW ·min/cm2 U V-irradiated cercariae were 10.62% and 20.17%, much lower than the above. No correlation between the degree of resistance and the times of immunization was found. The RPWB of single, double and triple vaccinations were 68.97%, 69. 46% and 71. 16% respectively. The results also showed that the resistance against S. japon-icum can last at least five months in mice. The RPWB were 71. 28%, 69. 63% and 60. 26% of immunization after one, three and five months. The although there's significant difference between them and seven months, the RPWB of seven months was 46. 25%, still high enough to show obvious resistance.
出处
《中国人兽共患病杂志》
CSCD
北大核心
1993年第3期17-20,共4页
Chinese Journal of Zoonoses
关键词
疫苗
减毒活疫苗
血吸虫病
预防
S. japonicum, Attenuated living vaccine, ultraviolet irradiation.
