摘要
用麻风菌经静脉内、后足垫和耳部皮下多途径接种裸鼠.结果表明能使裸鼠比单途径接种产生更高的菌量、更严重的病变和系统性播散。这说明在麻风的实验研究中,裸鼠麻风模型有很高的实用价值。
Immunodeficient nude have been inoculated with nude mouse-derived M.leprae through multiple routes,i.e.intravenously,subcutaneously at the foot pad and into the ear.The results showed that the inoculated animals were capable of producing a greater number of M.leprae,amounting to 1011-12 per gram tissue and distinct histopathological changes in lepromatous form.The disease could disseminate to sites with lower body temperature.The organism demonstrated a partiality for the striate muscles and peripheral nerves.The authors regard the nude mouse model as very useful tool for leprosy research,especially in countries without armadillo.As compared with inoculation through a single route reported previously,the inoculation through multiple routes seemed to be more practical.
