摘要
对64例老年人慢性肺源性心脏病患者血液中超氧化物歧化酶（SOD）及过氧化脂质(LPO)含量测定,结果发现急性发作期SOD含量明显降低,LPO含量明显增高,与缓解期组及对照组比较均有显著差异（P<0.O1）,SOD与LPO负相关（r=-0.988,P<0.01）,SOD与P_aO_2正相关（r=0.974,P<0.01）,与P_aCO_2负相关（r=-0.737,P<0.01）。而缓解期组与对照组比较无明显差异,说明氧自由基可能参与慢性肺源性心脏病急性发作期的病理生理过程。
Clinical significance of Determination of Blood SOD and LPO in old patients with Cor pulmonaleChen Meiyun Lin Qichang,Wu Wusong,et al(Departement of internal Medicine,Frist Affiliated Hospital of Fujian Medical College, Fuzhou)64 cases of patients with Cor pulmonale were determined,The results indicated that the contents of blood SOD in cases with Cor pulmonale of acute onset were remarkably decreased arid those of plasma Lpo were increased. Compared with relaxing cases and the normal controls,.the results were significant defference (P<0. 01). The contents of blood SOD correlated negatively with plasma Lpo (r=-0. 988,P<0. 01).,The contents of,blood SOD correlated positivly with PaQ2(r = 0. 974,P<0. 01)r The contents of .blood SOD correlated negatiyely ,with PaCO2(r=-0. 737, P<0. 01 ).But relaxing cases compared with, control were no significant changes. These results suggested that oxygen-free radical may be invclved in the pathophysilogical process of ,the acute cases.
关键词
老年人
肺心病
血液
SOD
LPO
超氧化物岐化酶
自由基
Cor pulmonale
superoxide dismutase
Lipid peroxidation oxyaen radicals
Free radicals
Vitamin E
