摘要
予高盐下卒中型自发性高血压大鼠 (SHRsp)饲料中分别补充海鱼鱼油 [含二十碳五烯酸 (EPA)和二十碳六烯酸 (DHA) ]和胆固醇 ,发现两种饲料能不同程度地降低血压和脑卒中发生率 。
This study was designed to investigate the effects of marine fish oil(FO) and cholesterol (Ch) on hypertensive target organs in salt loaded SHRsp.Thirty seven male SHRsp at 6 weeks of age were randomly divided into 3 groups:FO group (n=12),given a diet containing 7.0% EPA+DHA(eicosapentaenoic acid+docosahexaenoic acid);Ch group(n=12),diet containing 2.0% cholesterol;and C group(n=13)as control.Body weight was measured weekly,and SBP was measured before and 6 weeks after the experiment.The pathological changes in the brain and kidney were observed.SBP in the FO and Ch groups was significantly lower than that in the C group 6 weeks after the experiment (C:34.4±1.4;FO:28.2±\{1.9\};Ch:28.4±1.8 kPa).Marine fish oil and cholesterol significantly reduced the total cerebral stroke rate (C:100%;FO:25%;Ch:58.3%) and prolonged the lifespan (C:\{80.8\}±5.8;FO:111.3±9.5;Ch:106.8±8.6 days).There was no ischemic cerebral stroke in the FO group (C:\{69.2%\};FO:0;Ch:58.3%) and fewer hemorrhagic cerebral strokes in the Ch group (C:84.6%;FO:25%;Ch:16.7%).Cholesterol,however,aggravated pathological kidney changes (arteriosclerosis:C,\{30.7%\};FO,0;Ch,\{58.3%\}).
关键词
高血压
海鱼鱼油
血压
脑卒中
oral marine fish oil
cholesterol
spontaneously hypertensive rats(SHRsp)
blood pressure
stroke
