摘要
应用半侧垂体培养和腺垂体原代单层细胞培养方法观察了 NaF 对 PRL 基础分泌和 TRH、VIP 及 metoclopramide 诱发分泌的影响。结果是:1、氟中毒大鼠半侧垂体 TRH 诱发的 PRL 分泌降低。2、NaF 对腺垂体细胞 PRL 基础分泌和 TRH、VIP 和 metoclopramide 诱发分泌均具有抑制作用。提示氟中毒时氟化物可能通过对垂体的直接作用而抑制 PRL 分泌。
Effects of NaF on PRL release in dispersed anterior pituitary cells were observed.The results were that PRLbasal release and induced secretion by TRH,VIP and metoclopramide were both reduced when added NaF in medi-um of anterior pituitary cells.The reaction of PRL release on TRH was also seen decreased in cultured semipitu-itary with fluorosis.Our results indicated that fluoride may directly affect pituitary cells to inhibit PRL secretion.
出处
《中国地方病学杂志》
CAS
CSCD
1993年第6期326-328,共3页
Chinese Jouranl of Endemiology
基金
国家自然科学基金
关键词
催乳素
氟化物
血管活性肠肽
prolactin
NaF
TRH
VIP
metoclopramide
anterior pituitary
cell culture
