摘要
本文报告支气管肺灌洗200例。灌洗液标本处理后进行了五项生化测定:癌胚抗原,铁蛋白,溶菌酶,β_2-微球蛋白,分泌型 IgA。同时测定了铁蛋白、溶菌酶、β_2-微球蛋白的血清含量,目的在于探讨它们各自在临床应用的可能性以及数项指标的综合应用价值。结果表明:灌洗液中铁蛋白、溶菌酶测定值在肺良恶性病变组中有显著差异,而分泌型 IgA,β_2-微球蛋白、癌胚抗原无差异,同时比较了灌洗液中铁蛋白与分泌型 IgA 比值以及灌洗液与血清中铁蛋白比值对诊断肺癌的敏感性特异性,可作为肺癌辅助诊断的参考。结果还表明,矽肺灌洗液中磷脂含量与矽肺分期、脱尘时间、吸烟量与细胞数多少有一定关系。
At present reports on the effectiveness of bronchial alveolar lavage (BAL)for the diagnosis and therapy of pulmonary diseases have led to increasing use of this procedure.We investigated or/and managed 200 patients by BAL.This paper emphasizes its application to diagnoses of lung cancer.Five biochemistry elements of the BAL fluid(BALF) such as ferritin(F),secretic IgA,lysozyme(LZM),β_2-microglobulin (β_2-MG),carcinoembryonic antigen(CEA)were observed in a largo por- tion of the patients.The ferritin and LZM demonstrated significant differences between groups of benign and malignant lesions,however, CEA,β_2-MG or SIgA did not.If you take F BALF/SIgA BALF ratio less 0.5 and FALF/F serum ratio less 1 as adifferential diagnosis index, the sensitivity and specificity are 0.66 and 0.83 respectively. In addition,we found the phosphatide level of BALF in patients with silicosis is effected somehow by which stage of silicosis he is,at how long he has been from not exposed to the dust and how heavy(or often)he smokes.
关键词
支气管肺灌洗
癌胚抗原
铁蛋白
bronchial alveolar lavage
carcinoembryonic antigen
ferritin
lysozyme
β_2-microglobulin
secretic IgA
silicosis
