摘要
目的 研究围术期吸入麻醉药对脑区的作用。方法 4 5例患者随机均分为异氟醚组、七氟醚组、地氟醚组。记录围术期近似熵与关联维数。常规监测MAP ,HR ,SpO2 。结果 与入室后相比 ,3组患者在麻醉后表现为额叶与颞叶区的脑电抑制程度较高。 3组患者入室后与麻醉后相比较 ,关联维数、近似熵明显降低 ,差异有统计学意义 (P <0 0 5 ) ,术中与复苏、觉醒相比较 ,差异亦有统计学意义(P <0 0 5 )。在复苏与觉醒后 ,患者各个脑区的脑电变化表现为 :额叶、枕叶、颞叶的脑电活动度较高。结论 静吸复合麻醉下 ,吸入麻醉药对各个脑区的抑制程度不同 ,以额叶、颞叶的抑制程度较高 ,额叶、枕叶、颞叶区在复苏、觉醒时兴奋程度较高。
Objective To study the effect of inhalational anesthetics on brain cortices under inhalational and intravenous combined anesthesia. Methods 45 patients were randomly divided into isoflurane group (n=15), sevoflurane group (n=15) and desoflurane group (n=15). The narcosis was maintained with inhalational and intravenous combined anesthesia. The EEG non-linear parameters including approximate entropy (ApEn) and correlation dimension (D 2 ) were recorded during operation periods. BP, HR, and SpO 2 were monitored routinely. Results Comparing with that at entrance to the operating room, the EEG activities of frontal and temporal cortices after anesthesia were more suppressed than other cortices. Comparing with that at entrance to the operating room, ApEn and D 2 were significantly declined in the three experimental groups (P<0.05). Comparing with the data of intra-operation period, ApEn and D 2 were significantly higher after resuscitation and awakening in the three experimental groups (P<0.05). After resuscitation and awakening, the EEG activities of frontal, occipital and temporal cortices were still more intense than that of other cortices in the experimental groups. Conclusion Under inhalational and intravenous combined anesthesia, the degree of suppression of EEG activities of different cortices induced by inhalational anesthetics was not the same. The suppression was more marked in the frontal and temporal cortices, whereas EEG activities were more intense in the frontal, occipital and temporal cortices after resuscitation and awakening.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2005年第2期156-158,共3页
Medical Journal of Chinese People's Liberation Army
基金
国家自然科学基金资助课题 (编号 30 340 0 75)
关键词
脑电非线性
脑区
近似熵
关联维数
吸入麻醉药
EEG non-linear
brain cortices
approximate entropy (ApEn)
correlation dimension (D 2 )
inhalational anesthetics
