摘要
目的 :研究内源性儿茶酚胺是否参与白细胞介素 2 (IL 2 )的心脏作用。方法 :采用Langendorff离体心脏灌流模型 ,观察室性早搏次数、左室发展压 (LVDP)、左室舒张末压 (LVEDP)、心率 (HR)和冠脉流量 (CF)的变化。结果 :① 5 0U/mlIL 2增加离体心脏的室性早搏次数 ,增加LVDP、LVEDP、HR和CF。②利舍平 (reserpine)或普萘洛尔 (propranolol)预处理后 ,5 0U/mlIL 2对离体心脏的作用消失 ;phentolamine预处理后 ,不改变 5 0U/mlIL 2的离体心脏作用。③ 2 0 0U/mlIL 2增加离体心脏的室性早搏次数 ,对LVDP、LVEDP、HR和CF无显著增加作用。④reserpine或 propranolol预处理后 ,2 0 0U/mlIL 2增加离体心脏的室性早搏次数作用不明显 ,LVDP、HR和CF降低、LVEDP增高。结论 :内源性儿茶酚胺介导了IL 2的致离体心脏心律失常、正性变时和变力作用 ,较高浓度的IL 2抑制离体心脏的功能。
Aim: To explore whether endogenous catecholamine participates in the effect of interleukin-2 on the isolated heart. Methods: The number of premature ventricular contraction(PVC),left ventricular developed pressure(LVDP),left ventricular end-diastolic pressure(LVEDP),heart rate(HR)and coronary flow(CF)were recorded in isolated Langendorffperfused rat hearts. Results: ①50 U/ml IL-2 increased the PVC number,LVDP LVEDP,HR and CF.②Pretreatment of reserpine or propranolol abolished the cardiac effect of IL-2 at 50 U/ml,while pretreatment with phentolamine did not change the effect of IL-2.③200 U/ml IL-2increased the number of PVC,but did not increase LVDP,LVEDP,HR and CF.④After pretreatment of reserpine or propranolol,IL-2 failed to increase the number of PVC,but caused decrease of LVDP,HR and CF,and elevation of LVEDP. Conclusion: Endogenous catecholamine mediates the arrhythmogenic,positively chronotropic and inotropic effects of IL-2.IL-2 at 200 U/ml inhibits the cardiac function in the isolated rat heart.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2005年第1期51-54,共4页
Chinese Journal of Applied Physiology
基金
浙江省自然科学基金青年人才专项资金资助(RC990 3 8)
