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P2X_7受体介导的细胞信号传导研究进展 被引量：6

Advances in the Study of P2X_7-Mediated Signal Transduction
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摘要 P2X_7受体是最有特点的P2X家族核苷酸受体,有独特的结构和功能,近年的研究表明它可介导细胞信号传导,通过钙离子,P2X_7受体偶联2条信号途径:PLD的激活和IL-1β的分泌;P2X_7受体还介导P38、ERK、JNK3条MAPK信号通路的激活。P2X_7受体在不同细胞通过特定的PTK活化MAPK信号通路。 P2X_7, which belongs to the P2X nucleotide receptor family, is structurally and functionally unique. Recent studies demonstrated that it could mediate cellular signal transduction. P2X_7 couples two intracellular signal pathways through Ca^(2+) thereby leading to the activation of PLD and the secretion of IL-1β. Moreover, P2X_7 mediates the activation of signal transduction pathways of P38, ERK and JNK MAPK. Furthermore, P2X_7 activates MAPK pathways via specific PTKs in various cells. This article reviews the advances in the study of P2X_7 mediated signal transduction.
作者 聂坤(综述) 郑国光(审阅)
机构地区 中国医学科学院
出处 《医学分子生物学杂志》 CAS CSCD 2005年第1期30-33,共4页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.30100072)~~
关键词 P2X7受体 信号传导 MAPK P2X_7 Receptor signal transduction MAPK
分类号 Q26 [生物学—细胞生物学]
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参考文献22

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医学分子生物学杂志
2005年 第1期

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