摘要
本实验发现大鼠自然吸入谷尘1个月后,病变很轻;至3个月后,则出现肺间质性肉芽肿和轻度性纤维增生;而气管住入谷尘1个月后则病变较明显,呈小气道慢性炎症和局灶性肉芽肿样病变,少数病灶有纤维化趋势;至3个月后病变反而减轻,仅出现气管、支气管的慢性炎症。这提示不同染尘方法所引起的病变是有区别的,尤其对于含矽量较低且含有生物源性物质的有机粉尘。
The experiments showed that the inhalation of grain dust by rats for one month caused aslight lung injury, but for three months a granulomatous interstitial pneumonitis and a slightincrease in the fibrous tissue.The rats with intratracheal instillation of grain dust were shownan apparent lung injury such as inflammation of small airway, focal granulomatosis and fibrosis on some small scale, but lung injury has lightened after three months and only wasrevealed the chronic inflammation of trachea and bronchi. These results demonstrated thattwo methods of exposure to dust may cause different lung injury, especially for organic dustcontaining low silica and the biogenic sustances.
出处
《卫生毒理学杂志》
CSCD
1993年第2期80-82,共3页
Journal of Health Toxicology
关键词
染尘
病理
尘肺
粉尘
Dust exposure
Grain dust
Pulmonary pathology
