摘要
目的 探讨天麻钩藤饮改善高血压患者内皮功能的机理。方法 选择肝阳上亢型高血压患者 6 0例 ,随机分为两组 ,治疗组服用天麻钩藤饮 ,对照组服用非洛地平 ,分别检测两组治疗前后血清谷胱甘肽过氧化物酶(GSH- PX)和过氧化氢酶 (CAT)含量。结果 治疗后 ,两组 GSH- PX和 CAT含量均增加 (P<0 .0 1) ,但治疗组较对照组增加明显 (P<0 .0 1)。结论 天麻钩藤饮改善高血压患者内皮功能的机理可能是通过增加 GSH- PX和CAT含量 ,清除过多的氧自由基 ,防止血管内皮细胞脂质过氧化 ,从而改善患者的血管内皮功能。
Objective To discuss mechanism of tianmagouteng decoction to endothelium function in the hypertension of liver yang excessive patients.Methods 60 patients with hypertension were divided into two groups:the patients in tianmagouteng decoction group were treated by tianmagouteng decoction,the patients in felodipine group were treated by felodipine.After four weeks,the GSH-PX and CAT in all the cases were measured.Results After 4 weeks,the GSH-PX and CAT increased in both groups(P<0.01),but the tianmagouteng decoction group was higher than the felodipine group significantly(P<0.01).Conclusion The mechanism of tianmagouteng decoction to endothelium function in the hypertension patient is increasing the serum content of GSH-PX and CAT,thereby,preventing lipid supper oxidation in endothelium cell and amending endothelium function.
出处
《山东医药》
CAS
北大核心
2005年第1期12-13,共2页
Shandong Medical Journal
基金
湖南省科技厅科研基金项目 (No.0 3 SSY40 0 8)
