摘要
【目的】通过建立一种重型颅脑外伤局灶低温治疗的方法 ,初步探讨其治疗重型颅脑外伤的疗效。【方法】采用自由落体撞击模型 ,设定假颅脑外伤模型组、颅脑外伤模型组及局灶低温组 (使用 2 5℃水降温 )。取损伤相邻区脑组织分别检测其水、Na+ 、K+ 、Ca2 + 含量。同时观察其病理改变。【结果】颅脑外伤模型组与局灶低温组神经元损伤数明显多于假颅脑外伤模型组 (P <0 .0 1) ,但局灶低温组神经元损伤数显著少于颅脑外伤模型组 (P <0 .0 1)。颅脑外伤模型组与局灶低温组水、Na+ 含量均较假颅脑外伤模型组显著增加 (P<0 .0 1) ,但局灶低温组水、Na+ 含量明显低于颅脑外伤模型组 (P <0 .0 1)。K+ 含量的变化呈现与水含量的变化相反的趋势。Ca2 + 含量的变化与水含量的变化无一致性。【结论】建立了一种重型颅脑外伤新型低温治疗方法 。
To set up a new method of focal hypothermia therapy for rat following severe traumatic brain injury(STBI).Free-falling impact model was used in the study. Twenty-one rats were randomly divided into three groups: STBI group, focal hypothermia group (by circulating 25℃ water) and sham group. The contents of water and total sodium, potassium, calcium of the sustained brain close to traumatic brain tissue were detected and pathological changes were observed in three groups.The damaged neurons increased significantly in both STBI group and focal hypothermia group than those in sham group at 72 h after STBI (P<0.01). But the damaged neurons in STBI group were more than those in focal hypothermia group (P<0.01). Although the contents of water and total sodium were significant higher in both STBI group and focal hypothermia group than those in sham group at 72 h after STBI (P<0.01), these items were lower in focal hypothermia group than those in STBI group (P<0.01). There was reverse relationship between the change of decreasing total potassium and increasing water content. There was no consistence between the change of total calcium and water content.[Conclusion]A new method of focal hypothermia therapy for rat STBI is established and it may be important for the study of STBI.
出处
《医学临床研究》
CAS
2004年第6期616-619,共4页
Journal of Clinical Research
关键词
脑损伤/治疗
低温
brain injuries/TH
hypothemia
