摘要
目的研究骨髓间充质干细胞在治疗股骨头坏死动物模型的修复作用及价值。方法建立兔双侧股骨头内骨缺损模型 ,并分为 3组 ,A组为制作缺损而不填充任何材料 ,B组为单纯填充纳米人工骨 ,C组填充纳米人工骨和骨髓间充质干细胞的复合材料。对植入后 4周、8周、12周的股骨头行组织学检查。结果B组和C组在股骨头缺损修复成骨方面与A组有显著差异 ,C组差异性更大。结论骨髓间充质干细胞有较强的成骨作用 ,可促进股骨头坏死骨缺损的修复 ,对股骨头坏死的治疗有较大价值。
ObjectiveTo evaluate the effectiveness of mesenchymal stem cell (MSC) in osteonecrosis of the femoral head defect(ONFH) repair. MethodsAniaml model of ONFH defect were established with rabbits, which were divided into 3 groups, group A did not infill anything as control, nano Hydroxyapatite/collagen(nHAC) as group B, nHAC+MSC as group C. Histology change were investigated 4,8,12 weeks after operation respectively.Results groups B and C were different with group A. The difference between groups A and C was more significant. ConclusionMesenchymal stem cell has a strong activity of osteoconduction, it has a value in repairing the bone defect of ONFH and the treatment of ONFH. [
出处
《中国康复理论与实践》
CSCD
2005年第1期4-6,共3页
Chinese Journal of Rehabilitation Theory and Practice
基金
首都医学发展科研基金重大科技联合攻关项目 (2 0 0 2 1 0 0 7)
卫生部属 (管 )医疗机构临床学科重点项目。
关键词
股骨头坏死
骨缺损
骨髓间充质干细胞
兔
osteonecrosis of the femoral head
bone defect
bone mesenchymal stem cell
rabbit
