大剂量甲基强的松龙对大鼠急性脊髓损伤预防保护作用的研究被引量：17

The preventive effect of high-dose methylprednisolone on acute spinal cord injury in rats

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摘要目的:探讨大剂量甲基强的松龙对急性脊髓损伤大鼠神经功能的预防保护作用。方法:采用Allen's重物打击模型,大鼠随机分为对照组、脊髓损伤组、预防使用大剂量甲基强的松龙组。在脊髓损伤后24h和72h对大鼠进行神经功能评分(Tarlov评分),对损伤部位脊髓行病理形态学、超微结构及神经细胞凋亡观察。结果:与脊髓损伤组相比,预防使用大剂量甲基强的松龙组大鼠损伤脊髓的病理形态及超微结构改善;Tarlov评分明显提高;神经细胞凋亡明显减少。结论:预先使用大剂量甲基强的松龙对大鼠急性脊髓损伤有预防性保护作用。 Objective:To study the preventive effect of high-dose methylprednisolone on acute spinal cord injury in rats.Method:The rats were randomly divided into three groups:Control groups,acute spinal cord injury groups(SCI),and administration of methylprednisolone prophylaxis groups(MP).Allen′s weight drop model of acute spinal cord injury was carried out.Tarlov′s motor scales,pathological and ultrastructural changes of spinal cord and apoptosis of spinal cord at 24h and 72h after SCI were sequentially studied.Result:The pathological and ultrastructural changes of spinal cord were significantly improved in the MP group than the SCI group.Tarlov′s motor scales incresed significantly at 72h after SCI in the MP group.The number of cells apoptosis in spinal cord decreased significantly in the MP group than in the SCI group.Conclusion:There is a neuroprotective effect of high-dose methylprednisolone for acute spinal cord injury in rat.

作者杨建东李家顺贾连顺钱列曹师峰邵将陈宣维

机构地区第二军医大学附属长征医院骨科

出处《中国脊柱脊髓杂志》 CAS CSCD 2005年第1期46-48,i002,共4页 Chinese Journal of Spine and Spinal Cord

关键词甲基强的松龙脊髓损伤 Tarlov评分凋亡 Methylprednisolone Spinal cord injury Tarlov′s motor scale Apoptosis

分类号 R683.2 [医药卫生—骨科学] R977.1 [医药卫生—药品]

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