摘要
目的探讨大剂量盐酸纳洛酮在重型脑外伤中的运用效果及其临床意义。方法除常规治疗外,入院或手术后纳洛酮组即给予纳洛酮0.4mg/kg/d,24小时持续给药;观察该组与常规组患者的伤情、脑水肿程度及预后并进行比较。结果纳洛酮组意识转清的患者明显多于常规组;纳洛酮组重度脑水肿病例数少于常规组;纳洛酮组预后良好病例数明显多于常规组。结论纳洛酮能有效阻断外伤后继发性脑损害,使昏迷和呼吸抑制的病人快速逆转意识障碍,解除呼吸抑制,减轻脑水肿,改善预后;使用中应掌握超早期、大剂量、持续给予的原则。
Objective To assess clinical effects of large dose Naloxone and its significance in severe brain injury. Methods Besides routine treatment, Naloxone group was treated with persistent Naloxone 0.4mg/kg/d after admission or operation. Then injury severity, brain edema and outcome were observed and compared in Naloxone group and routtine group. Results More patients became conscious in Naloxone group than that in routine group. The patients with severe brain edema were less in Naloxone group than in routine group. The patients with good outcome were more in Naloxone group than in routine group. Conclusions Naloxone can effectively prevent secondary brain injury, rapidly reverse disturbance of consciousness and absolve breath depression, relieve brain edema and improve outcome. The principle of super-early time, large dose and persistence should be grasped in using.
出处
《海南医学》
CAS
2005年第3期31-32,共2页
Hainan Medical Journal
关键词
纳洛酮
颅脑损伤
伤情
脑水肿
预后
Naloxone
Brain injury
Injury severity
Brain edema
Outcome
