老年2型糖尿病合并血管并发症患者血白细胞和游离脂肪酸的变化被引量：5

Changes of WBC Count and Free Fatty Acid Level in Elder Type 2 Diabetic Patients with Angiopathy

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摘要目的　研究 2型糖尿病 (T2DM)和T2DM合并血管并发症患者血白细胞和游离脂肪酸 (FFAs)的变化及其相关性 ,探讨白细胞和游离脂肪酸在T2DM血管并发症发生中的作用。方法　用血细胞计数法测定 3 8例T2DM伴血管并发症组、2 2例T2DM无血管并发症组及 2 0例正常人组的白细胞数 ,用发色底物法测定三组病人的空腹血清FFAs水平 ,并将白细胞数与FFAs浓度做相关性分析。结果　⑴DM组与正常对照组比较 ,血白细胞计数、游离脂肪酸水平显著升高 (P <0 0 5 )。⑵T2DM有血管并发症组与无血管并发症组比较 ,血白细胞计数、游离脂肪酸水平显著升高 (P <0 0 5 )。⑶有并发症组白细胞数与FFAs呈显著正相关 (r =0 3 66,P <0 0 5 ) ,FFAs与无并发症组亦呈正相关 (r =0 42 4,P <0 0 5 )。结论　T2DM合并血管并发症患者血白细胞数、FFAs升高 ,白细胞可与FFAs一样作为非特异性炎症的生物标志物。 Objective To investigate the changes of WBC count and free fatty acids (FFAs) level in diabetic patients with angiopathy, and explore the role of WBC and FFAs in the pathogenesis of diabetic angiopathy. Methods The number of WBC and the concentration of FFAs were determined in 22 diabetic patients without angiopathy, 38 diabetic patients with angiopathy and 20 healthy subjects. Results Both WBC count and FFAs concentration in the diabetic patients were obviously higher than those in healthy subjects (P<0.05), and in diabetic patients with angiopathy were also significantly higher than those in diabitic patients without one (P<0.05). WBC count was positively correlated with FFAs concentration in diabetic patients with angiopathy. Conclusion Both WBC count and FFAs concentration increased in diabetic patients with angiopathy. WBC count may be a biological mark for inflammation as FFAs.

作者邓满香刘慧霞张骥杨幼波

机构地区中南大学湘雅医院老干科

出处《中国医师杂志》 CAS 2005年第1期43-45,共3页 Journal of Chinese Physician

关键词 2型糖尿病血管并发症白细胞游离脂肪酸老年人 Type-2 diabetes mellitus Angiopathy WBC FFAs

分类号 R587.1 [医药卫生—内分泌]

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