摘要
本文以人工合成肽GOR作为包被抗原建立ELISA法检测患者血清中HCV感染相关自身抗体(抗-GOR)。检测581份各类临床标本,其中急、慢性NANBH的抗-GOR阳性率分别为19.2％和25.7％,而属于甲、乙型急慢性肝炎、SLE等均在10％以下。抗-GOR总检出率低于抗-HCV,但两者间具有互补性,且抗-GOR效价与HCV核心抗体有很好的相关性。以上结果表明:①GOR抗体的出现与HCV感染有关。②同时检测抗-GOR和抗-HCV可提高HCV感染的诊断率。③HCV感染的致病可能是通过HCV核心蛋白和自身蛋白联合触发而诱导机体产生自身抗体即抗-GOR。
We synthesized a peptids GOR as antigen for detection of HCV infection-associated autoimmune antibody with ELISA. 581 serum samples from various clinical groups were tested for anti-GOR and the antibodies were detected in 19.2% patients with acute NANBH, 25.7% with chronic NANBH but in less than 10% patients with HA,HB and SLE,etc. The positive rate of anti-GOR in NANBH was lower than that of anti-HCV, but they were complementary to each other. The antibody to GOR was well related to the HCV core antibody. The results showed:(1).Antibody to GOR was related to HCV infection. (2). Detecting both anti-GOR and anti-HCV at the same time, we could improve the diagnosis rate of HCV infection. (3). HCV infection was possibly due to the combination of HCV core protein with host protein, inducing the host to produce the auto-antibody (anti-GOR).
出处
《上海免疫学杂志》
CSCD
北大核心
1993年第5期287-290,共4页
Shanghai Journal of Immunology
基金
国家自然科学基金
