摘要
目的探讨诱导型一氧化氮合酶(iNOS)在胃不典型增生、胃癌中的表达及其在胃癌中与肿瘤微血管密度(MVD)的关系。方法采用免疫组化Powervision两步法对84例胃癌和54例胃不典型增生组织中iNOS及CD34的表达进行检测并计数MVD。结果iNOS在胃轻度不典型增生、重度不典型增生及胃癌组织中阳性表达率分别为36.36%、57.14%、77.38%,其中胃癌与轻度不典型增生组之间的差异有统计学意义(P<0.01)。iNOS的表达与肿瘤的大小、淋巴转移、MVD相关(P<0.05或P<0.01)。结论iNOS与胃癌的发生、浸润转移、MVD相关,促进血管生成为iNOS促进胃癌进展的机制之一。
Objective To explore the expression of iNOS in gastric atypical hyperplasia and gastric cancer and its relationship to microvascular density (MVD). Methods The expression of iNOS and CD34 were determined by Power vision immunohistochemical analysis in 84 gastric cancers and 54 gastric atypical hyperplasias. The MVD in gastric cancer was counted by referring to the positivity of CD34. Results Positive rate of iNOS(77.38%)in gastric cancer was significantly higher than those in gastric atypical hyperplasia(P<0.05). The overexpression of iNOS in gastric cancer was related to lymph node metastasis, tumor size and MVD(P<0.05). Conclusions The expression of iNOS may play important roles in the pathogenesis of gastric cancer, with enhancing angiogenesis as one of its mechanisms.
出处
《徐州医学院学报》
CAS
2005年第1期3-6,共4页
Acta Academiae Medicinae Xuzhou
基金
江苏省教育厅自然科学研究计划项目(01KJB320011)
