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热休克预处理对兔肝缺血再灌注损伤的影响

Effects of heat shock pretreatment on liver ischemia and reperfusion injury in rabbits
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摘要 目的 :探讨热休克预处理对肝缺血 再灌注损伤的影响 .方法 :随机将家兔分为对照组和热休克预处理组 ,复制肝脏缺血 再灌注模型 ,分别于缺血前、缺血 4 5min、再灌注 4 5min取血 ,赖氏法检测血清丙氨酸氨基转移酶 (Alanineamino transferase,ALT)活性 .结果 :热休克预处理组缺血前的ALT活性高于对照组 (0 .31± 0 .0 4 ) μkat/L→ (0 .17± 0 .0 2 ) μkat/L (P<0 .0 1) ,但缺血 4 5min及再灌注 4 5minALT活性显著低于对照组 (0 .4 6± 0 .0 6 ) μkat/L→ (0 .6 8± 0 .0 9) μkat/L ,(0 .5 7± 0 .0 5 ) μkat/L→ (1.34± 0 .0 5 ) μkat/L (P <0 .0 1) .结论 :热休克预处理对肝细胞有损伤作用 ,但对缺血 再灌注损伤有明显的保护作用 .
作者 罗友根 尹敬德
机构地区 井冈山医学院生理学教研室
出处 《第四军医大学学报》 北大核心 2005年第1期F003-F003,共1页 Journal of the Fourth Military Medical University
关键词 热休克预处理 缺血-再灌注损伤 丙氨酸氨基转移酶
分类号 R554 [医药卫生—血液循环系统疾病]
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参考文献6

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二级参考文献12

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第四军医大学学报
2005年 第1期

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