摘要
膜磷壁酸 (Lipoteichoicacid ,LTA)是革兰阳性菌胞壁的共有成分 ,通过D 丙氨酸这一关键位点发挥黏附机体细胞和免疫刺激作用。机体对LTA的应答和清除涉及到LBP ,CD14等蛋白和单核细胞 ,中性粒细胞等免疫细胞 ,是一个多步骤的复杂过程。血浆脂蛋白 (HDL、LDL、VLDL)有结合LTA的巨大容量。除了引发炎症外 ,LTA还具有抗肿瘤 ,防止组织缺血再灌注损伤等生物学效应。
Lipoteichoic acids (LTAs) are the common cell wall component of Gram-positive bacteria. D-alanine is required for adhesion and virulence of LTA. The recognition and clearance of LTA is a complex and multisteps process involving serum-proteins (LBP, CD14 et al.) and immunological cells (monocytes, neutrophils et al.). Serum lipoproteins (HDL, LDL, and VLDL) have enough capability to bind with LTA. The response of host to LTA results in anti-tumor, reduction of ischemia/reperfusion injury, and inflammation. Novel ways are searched to resist the virulence of LTA through chemical drugs and synthesis of antimicrobial peptides.
出处
《免疫学杂志》
CAS
CSCD
北大核心
2005年第1期72-74,76,共4页
Immunological Journal
关键词
膜磷壁酸
分子识别
信号传导
生物学效应
Lipoteichoic acid
Recognition of molecular
Signal conduction
Biological effect
