摘要
报道并分析20例小儿糖尿病患儿的临床资料及血胰岛细胞抗体(ICA)及胰岛素自身抗体(IAA)的测定资料。在20例患儿中,临床表现多不典型。在酮症酸中毒的治疗中小剂量胰岛素疗法方法简便,安全可靠,并发症少。本组患儿ICA阳性率55%,IAA阳性率30%,经卡方检验均显著高于对照组,推测病毒感染引起自身免疫反应,产生ICA及IAA而致本病发生。
Clinical and experimental findings of isdet cell cytoplasmic antibody(ICA) and insulin antoantibody(IAA)in 20 children with diabetes mellitus wetre reported.The clinical manifestations were unclassical in these patients. Treatment of ketoacidosis of pa- tients with low dosage of insulin offered satisfactory clinical results and without complica- tions.The enchanced ICA and IAA were found in 55% and 33% od patients respectively and were significantly higher than that in normal controls analyzed by Chi-square test.These ob- servations suggest that the autoimmune reaction is possibly due to virus infection in vivo. The reaction may result in the production of ICA and IAA,destruction of the beta cells and subsequent occurrence of diadetes mellitus.
关键词
糖尿病
自身抗体
儿童
diabetes mellitus
autoantibody
children
