摘要
AIM: To investigate the protective effect of ischemic preconditioning (IPC) on hepatocellular carcinoma (HCC) patients with cirrhosis undergoing hepatic resection under hepatic inflow occlusion (HIO) and its possible mechanism.METHODS: Twenty-nine consecutive patients with resectable OHCC were randomized into two groups: IPC group: before HIO, IPC with 5 min of ischemia and 5 min of reperfusion was given; control group: no IPC was given. Uver functions,hepatic Caspase-3 activity, and apoptotic cells were compared between these two groups.RESULTS: On postoperative days (POD) 1, 3 and 7, the aspartate transaminase (AST) and alanine transaminase (ALT) levels in the IPC group were significantly lower than those in the control group (P<0.05). On POD 3 and 7, the total bilirubin level in the IPC group was significantly lower than that in the control group (P<0.05). On POD 1, the albumin level in the IPC group was higher than that in the control group (P = 0.053). After 1 h of reperfusion, both hepatic Caspase-3 activity and apoptotic sinusoidal endothelial cells in the IPC group were significantly lower than those in the control group (P<0.05).CONCLUSION: IPC has a potential protective effect on HCC patients with cirrhosis. Its protective mechanism underlying the suppression of sinusoidal endothelial cell apoptosis is achieved by inhibiting Caspase-3 activity.
AIM:To investigate the protective effect of ischernic preconditioning(IPC)on hepatocellular carcinoma(HCC) patients with cirrhosis undergoing hepatic resection under hepatic inflow occlusion(HIO)and its possible mechanism. METHODS:Twenty-nine consecutive patients with resectable 0HCC were randomized into two groups:IPC group:before HIO,IPC with 5 min of ischemia and 5 min of reperfusion was given;control group:no IPC was given.Liver functions, hepatic Caspase-3 activity,and apoptotic cells were compared between these two groups. RESULTS:On postoperative days(POD)1,3 and 7,the aspartate transaminase(AST)and alanine transaminase (ALT)levels in the IPC group were significantly lower than those in the control group(P<0.05).On POD 3 and 7,the total bilirubin level in the IPC group was significantly lower than that in the control group(P<0.05).On POD 1,the albumin level in the IPC group was higher than that in the control group(P=0.053).After 1 h of reperfusion,both hepatic Caspase-3 activity and apoptotic sinusoidal endothelial cells in the IPC group were significantly lower than those in the control group(P<0.05). CONCLUSION:IPC has a potential protective effect on HCC patients with cirrhosis.Its protective mechanism underlying the suppression of sinusoidal endothelial cell apoptosis is achieved by inhibiting Caspase-3 activity.
