摘要
16例急性早幼粒细胞白血病患者血清TNF活性明显高于正常对照(P<0.05),而经RA诱导分化治疗中期及治疗后明显降低(P<0.05),但仍高于正常对照组。各治疗时相的外周白细胞胞浆内TNF平均水平及正常对照间均无明显差别(P>0.05),治疗前及治疗中期胞浆TNF活性升高率明显高于治疗后或正常对照(P<0.05)。相关分析表明:血清TNF活性水平与外周血WBC总数或骨髓GM-CFU无明显相关,而与骨髓L-CFU变化具相关性(P<0.01)。体外rhTNF抑制正常造血,RA轻度促进造血,ATRA+TNF可拮抗TNF对正常造血的抑制。RA、TNF或RA+TNF均明显抑制NB_4细胞株体外增殖(P<0.05)。
In our study,we found that serum level of TNF activity in 16 cases of patient with acute promyelocytic leukemia(APL)was obviously higher than that of normal controls(P<0. 05). During intermi-tant period (total number of WBC growth )or post-treatment with retinoic acid (RA) .serum level of TNF activity significantly decreased (P<0. 05). The TNF level intro WBC was not obvious defferent within three groups of APL(P>0. 05) or each of them not different from normal controls(P>0. 05) .but the percent of in-creasement of the before or the intermitant was higher than that of the after of treatment with RA or than normal controls (P<0. 05). Analysis of relation showed that serum level of TNF activity was significantly related to the L-CFU(P<CO. 05) only. Experiment in vitro showed that rhTNF inhibited the growth of normal hemapoitic cells(P<0. 05),otherwise,RA could antigonist the inhibiting effection. On the other hand.RA , TNF or RA+TNF all could inhibit NB4 cells growth(P<0. 05).
出处
《免疫学杂志》
CAS
CSCD
北大核心
1993年第4期250-254,共5页
Immunological Journal
基金
国家八五攻关课题资助
