摘要
目的 :观察辛伐他汀治疗稳定型心绞痛 ( SAP)、急性冠脉综合征 ( ACS)患者 4周后基质金属蛋白酶 - 9( MMP- 9)和 C-反应蛋白 ( CRP)的变化 ,以了解辛伐他汀治疗对斑块稳定性的影响。方法 :将 30例 SAP和 30例 ACS患者分为他汀治疗组和常规治疗组 ,测定治疗前后 MMP- 9和 CRP水平。结果 :经辛伐他汀治疗后 ,治疗组 MMP- 9和 CRP水平明显降低 ,与治疗前比较有统计学差异 ( P<0 .0 0 1)。结论 :辛伐他汀治疗可明显减轻炎症因子 MMP- 9和 CRP水平 。
Objective:To observe the effects of simvastatin on matrix mata lloproteiases 9(MMP 9),c reactive protein(CRP) level in patients with stable an gina pectoris(SAP) and acute coronary syndrome(ACS). Methods:Thirty SAP and th irty ACS patients were randomly divided into either the simvastatin group or the control group. The levels of MMP 9 and CRP before and after treatment were detected.Results:After treatment with simvastatin,the levels of MMP 9 and CRP in both two groups significantly decreased (P<0. 001).Conclusion:Simvastatin decreased level of inflammatory factors in the patients of SAP and ACS, so it could benefit to atherosclerotic plaque stabilization.
出处
《中国误诊学杂志》
CAS
2004年第10期1590-1591,共2页
Chinese Journal of Misdiagnostics
