期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

多药耐药基因与血迷路屏障外向运输研究进展

暂未订购
导出
摘要 血迷路屏障通透性是耳科研究的一个重要领域。近年来 ,在血迷路屏障微血管内皮细胞和边缘细胞中发现多药耐药 (multidrugresistance ,MDR)基因及编码的蛋白参与血迷路屏障的分泌、排泄和防护功能 ,揭示了血迷路屏障通透性一种新的机制。本文就MDR基因及编码的蛋白在血迷路屏障外向性运输中的作用做一综述。
作者 周亚光 张学渊
机构地区 成都军区昆明总医院耳鼻咽喉科 第三军医大学西南医院耳鼻咽喉科
出处 《国外医学（耳鼻咽喉科学分册）》 2004年第6期349-351,共3页 Foreign Medical Sciences(Section of Otolray Ngology Foreign Medical)
关键词 多药耐药基因 血迷路屏障 外向运输 研究进展 微血管 内皮细胞
分类号 R764 [医药卫生—耳鼻咽喉科]
  • 相关文献

参考文献23

  • 1Croop JM, Raymond M, Haber D, et al. The three mouse multidrug resistance(mdr) genes are expressed in a tissue-specific manner in normai mouse tissues. Mol Cell Biol. 1989; 9: 1346-1350.
  • 2Ueda K. Expression of a full-length cDNA for the human "MDR" gene confers resistance to clolchicinedoxorubicin and vinblastine. Proc Natl Acad Sci USA. 1987; 84: 3004-3008.
  • 3Schinkel AH, Smit JJ, van Tellingen O, et al. Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell. 1999; 7:491-502.
  • 4Gaillard PJ, van der Sandt IC, Voorwinden LH, et al. Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier. Pharm Res. 2000; 17: 1198-1205.
  • 5陈修煦.p53突变、微卫星不稳定性与多药耐药[J].国外医学（遗传学分册）,1999,22(3):137-142. 被引量：3
  • 6Button B, Reuss L, Altenberg GA, et al. PKC-mediated stimulation of amphibian CFTR depends on a phosphorylation consensus site. insertion of this site confers PKC sensitivity to human CFTR. J Gen Physiol. 2001; 117: 457-468.
  • 7Hartmann G, Kim H, Piquette-Miller M. Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int Immunopharmacol. 2001; 1: 189-199.
  • 8Whitehead RP, Unger JM, Flaherty LE, et al. Phase Ⅱ trial of CI-980 in patients with disseminated malignant melanoma and no prior chemotherapy. A Southwest Oncology Group study. Invest New Drugs.2001; 19: 239-243.
  • 9Abraham EH. Erythrocyte membrane ATP binding cassette(ABC) proteins: MRP1 and CFTR as well as CD39 (ect-apyrase) involved in ABC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis. 2001; 27: 165-180.
  • 10Warren KF, Patel MC, McCully CM, et al.Effect of P-glycoprotein modulation with cyclosporin A on cerebrospinal fluid penetration of doxorubicin in non-human primates. Cancer Chemother Pharmacol. 2000; 45: 207-212.

二级参考文献6

  • 1SpectorDL,GoldmanRD,LeinwandLA.Cell:ALaboratoryManual[]..1998
  • 2Sugimoto Y,Aksentijevich I,Gottesman MM,et al.Efficient expression of drug-selectable genes in retroviral vectors under control of an internal ribosome entry site[].Bio Technology.1994
  • 3Licht T,Herrmann F,Gottesman MM,et al.In vivo drug-selectable genes: a new concept in gene therapy[].Stem Cells.1997
  • 4Moreb JS,Schweder M,Gray B,et al.In vitro selection of K562 cells with higher retrovirally mediated copy number of aldehyde dehydrogenase class-1 and higher resistance to 4-hydroperoxycyclophosphamide[].Human Gene Therapy.1998
  • 5Pelletier J,Sonenberg N.Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from polivirus RNA[].Nature.1988
  • 6Hildinger M,Fehse B,Hegewisch BS,et al.Dominant selection of hematopoietic progenitor cells with retroviral MDR1 coexpression vectors[].Human Gene Therapy.1998

共引文献6

国外医学（耳鼻咽喉科学分册）
2004年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部