期刊文献+

小鼠内耳毛细胞基因及其功能 被引量:2

暂未订购
导出
摘要 近年分子遗传学和遗传工程的飞速发展 ,不仅加速确定了许多内耳感觉毛细胞基因 ,而且为进一步明确这些基因的功能 ,阐明它们在毛细胞分化、生长和成熟过程中的作用产生了重要的影响。小鼠转基因和通过胚胎干细胞技术的基因敲除 ,分别揭示了一些毛细胞基因存在基因编码的特异性启动子和它们的功能。本文从毛细胞发育和成熟的不同阶段 ,对部分内耳毛细胞基因的表达和功能进行了概述。
出处 《国外医学(耳鼻咽喉科学分册)》 2004年第6期340-345,共6页 Foreign Medical Sciences(Section of Otolray Ngology Foreign Medical)
  • 相关文献

参考文献25

  • 1Ben-Arie N, Bellen HJ, Armstrong DL, et al. Math1 is essential for genesis of cerebellar granule neurons. Nature. 1997; 390: 169-172.
  • 2Bermingham NA, Hassan BA, Price SD, et al. Math1: an essential gene for the generation of inner ear hair cells. Science. 1999; 284:1837-1841.
  • 3Chen P, Johnson JE, Zoghbi HY, et al. The role of Math1 in inner ear development: uncoupling the establishment of the sensory primordium from hair cell determination. Development. 2002; 129: 2495-2505.
  • 4Zheng JL, Gao WQ. Overexpression of Math1 induces robust production of extra hair cells in postnatal rat inner ears. Nat Neurosci. 2000;3: 580-586.
  • 5Xiang M, Gao WQ, Hasson T, et al. Requirement for Brn-3c in maturation and survival, but not in fate determination of inner ear hair cells. Development. 1998; 125: 3935-3946.
  • 6Xiang M, Gan L, Li D, et al. Essential role of POU-domain factor Bin3c in auditory and vestibular hair cell development. Proc Natl Acad Sci USA. 1997; 94: 9445-9450.
  • 7Boeda B, Weil D, Petit C. A specific promoter of the sensory cells of the inner ear defined by transgenesis. Hum Mol Genet. 2001; 10:1581-1589.
  • 8Liu X, Udovichenko IP, Brown SD, et al. Myosin Ⅶa participats in opsin transport through the photoreceptor cilium. J Neurosci. 1999;19: 6267-6274.
  • 9Kros C J, Marcotti W, van Netten SM, et al. Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations. Nat Neurosci. 2002; 5: 41-47.
  • 10Gillespie PG. Myosin-Ⅶa and transduction channel tension. Nat Neurosci. 2002; 5: 3-4.

同被引文献20

  • 1孙建和,杨伟炎,方耀云,朱光明,侯宁.豚鼠耳蜗毛细胞静纤毛连接桥的扫描电镜观察[J].电子显微学报,2005,24(4):415-415. 被引量:2
  • 2宇雅苹,杨仕明.小鼠内耳发育的分子生物学研究进展[J].听力学及言语疾病杂志,2006,14(5):386-390. 被引量:2
  • 3Beghini A,Magnani I,Roversi G, et al. The neural progenitor-restricted isoform of the MARK4 gene in 19q13. 2 is upregulated in human gliomas and overexpressed in a subset of glioblastoma cell lines[J]. Oncogene,2003,22:2581.
  • 4Kato T, Satoh S, Okabe H, et al. Isolation of a novel human gene, MARK1, homologous to MARK3 and its involvement in hepatocellular carcinogenesis[J]. Neoplasia,2001, 3:4.
  • 5Lizcano JM,Goransson O,Toth R,et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1[J]. EMBO J, 2004,23:833.
  • 6Trinczek B,Brajenovic M,Ebneth A,et al. MARK4 is a novel microtubule- associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomes[J]. J Biol Chem,2004,279: 5915.
  • 7Chen AH, Ni L, Fukushima K, et al. Linkage of a gene for dominant non- syndromic deafness to chromosome 19 [J]. Hum Mol Genet,1995,4:1073.
  • 8Mirghomizadeh F, Bardtke B, Devoto M, et al. Second family with hearing impairment linked to 19q13 and refined DFNA4 localisation[J]. Eur J Hum Genet,2002,10 : 95.
  • 9Donaudy F, Snoeckx R, Pfister M, et al. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4)[J]. Am J Hum Genet, 2004,74: 770.
  • 10Yang T, Pfister M, Blin N, et al. Genetic Heterogeneity of Deafness Phenotypes Linked to DFNA4[J]. Am J Hum Genet, 2005,139A:9.

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部