摘要
目的:探讨组织压迫时间与脊髓损伤程度及神经功能恢复的关系。方法:20只犬随机分为两组,应用水囊压迫造成脊髓损伤,分别压迫30min和180min。在压迫期间和去除压迫后不同时间监测躯体感觉诱发电位(SSEP)和脊髓灰质血流量。去除压迫后不同时间进行后肢运动功能评价,去除压迫后28天处死动物进行组织学评价。结果:脊髓压迫期间SSEP波幅迅速下降并消失。30min组去除压迫后SSEP波幅缓慢恢复,180min组始终无恢复(P<0.05)。加压后两组血流量迅速下降,去除压迫即刻两组血流量差异有显著性(P<0.05)。后肢运动功能检查30min组恢复较快,180min组较慢(P<0.05)。180min组较30min组组织损伤重(P<0.05)。结论:脊髓压迫时间越长组织破坏程度越重,神经功能恢复时间越长,效果越差。脊髓受压后尽早行减压术有利于神经功能恢复。
Objective:To investigate the relationship between sustained spinal cord compression and neuronal functional recovery.Method:Twenty dogs underwent sustained spinal cord compression for 30 or 180 minutes.The cords were compressed with the loading device of a hydraulic piston.Somatosensory evoked potentials and regional blood flow were monitored during the period of sustained compression as well as the certain time after the decompression.Functional motor recovery was judged throughout a 28-day period after the injury.The lesion and damage to the tissue were assessed with histological analysis in 28th day the end of the experiment.Result:There was continuous decline in the amplitude of the somatosensory evoked potentials,which did not recover until the cord was decompressed. After the decompression,the dogs in the 30-minute-compression group had recovery of somatosensory evoked potentials,but the 180-minute-compression group had not(P<0.05).Regional blood flow decreased rapidly,there was a significant difference between 30-minute-compression group and 180-minute-compression group at the decompression time(P<0.05).Motor tests demonstrated rapid recovery of hindlimb motor function in the 30minute group that was significantly better than in the 180minute group.The longer duration of compression produced significantly greater lesions.Conclusion:Longer periods of compression resulting in a lack of recovery of somatosensory evoked potentials, imited functional recovery and more extensive tissue damage.The findings underscore the importance of timely decompression to improve long-term functional recovery after spinal cord injury.
出处
《中国康复医学杂志》
CAS
CSCD
2004年第9期657-660,共4页
Chinese Journal of Rehabilitation Medicine
基金
河北省科技攻关资助项目(04276101D)
