摘要
目的 :探讨狼疮肾炎患者血、尿单核 巨噬细胞趋化蛋白 1(MCP 1)的变化及其意义。方法 :应用酶联免疫法 (ELISA)分别检测 3 6例狼疮肾炎和 2 0例健康对照者血、尿MCP 1的水平。结果 :狼疮肾炎患者血、尿MCP 1水平较正常对照者明显升高(均为P <0 .0 1) ;狼疮肾炎患者活动期尿MCP 1水平较静止期明显增高 (P <0 .0 1) ,而血MCP 1水平差异不大 (P >0 .0 5 ) ;活动期患者经激素或细胞毒药物治疗后尿MCP 1明显下降 (P <0 .0 1) ,血MCP 1下降不明显 (P >0 .0 5 )。结论 :尿MCP 1的测定可作为反映狼疮肾炎活动的一个有用指标。
Objective To analyse the relationship and signifi c ance between serum and urinary monocyte chemoattractant protein-1(MCP-1) in pa tients with lupus nephritis.Methods The levels of serum and uri n ary MCP-1 of the 36 cases of patients with lupus nephritis and 20 cases in cont rol group were measured using enzyme-linked immunoabsorbent assay (ELISA). Results The levels of serum and urinary MCP-1 in patients with lupus nephritis were significantly higher than those in the control group.The level of urinary MCP-1 in patients with lupus nephritis whose lesion was active was sig nificantly higher than that in those patients whose lesion wa s silent,but the level of serum MCP-1 did not significantly change in patie nts whose lesion was silent or active. After treatment with glucocorticoid or cy c lophosphamide to the patients whose lesion was active, the level of urinary MCP -1 descended significantly .However the level of serum MCP-1 did not change dramatically.Conclusions The change of serum and urinary MCP -1 in the lupus nephrit is patients suggest that MCP-1 correlates to the pathogenesis of lupus ne phritis;When the lesion of lupus nephritis is active,the level of urinary MCP-1 is significantly higher than those whose lesion is silent. Glucocorticoid or cyclophosphamide can significantly decrease the level of urinary MCP-1 whose l esion is silent after treatment.
出处
《南京铁道医学院学报》
2004年第6期409-411,共3页
Journal of Nanjing Railway Medical College
